Article
PIEZO1 regulates smooth muscle cell plasticity by integrating mechanical stretch with glycolytic metabolism.
Cardiovascular research - 28 Apr 2026
Cao Yapeng, Xu Liran, Zhang Min, Su Ailing, Wang Siyu, Li Ting, Liu Siyu, Mao Ziyang, He Yu, Shao Zehua, Zhang Jiamin, Wang Youhua, Tian Huijing, Sun Yuzhuo, Li Yongxin, Yan Luqin, Zhang Guangjian, Sun Shiquan, Mei Na, Chen Fangyuan, Xiong Ying, Liang Guozheng, Offermanns Stefan, Yan Yang, Yuan Zuyi, Wang Shengpeng
Abstract excerpt
AIMS: Pulmonary artery smooth muscle cells (PASMCs) sense and respond to constant mechanical strain, which is vital for lung homeostasis and disease. Mechanical stimuli and altered glycolytic metabolism are intrinsically intertwined in proliferative PASMCs undergoing a phenotypic switching, however, it remains unclear how biophysical forces and glycolysis are coupled in PASMCs. We report that PIEZO1 plays a...
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