Article

Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells

2024-05-30

Abstract excerpt

<h4>ABSTRACT</h4> Hypoxia-inducible factor 1α (HIF1α) is a master regulator of numerous biological processes under low oxygen tensions. Yet, the mechanisms and biological consequences of aerobic HIF1α activation by intrinsic factors, particularly in primary cells remain elusive. Here, we show that HIF1α signaling is activated in several human primary vascular cells under ambient oxygen tensions, and in vascular s...

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Literature Corpus work: 9e900e5b-76bd-55a2-84f5-7b4fbf639330
DOI: 10.1101/2024.05.29.595538

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Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cellsDOI 10.1101/2024.05.29.595538Read

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