Article
Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation.
American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2020
Joshi Sachindra Raj, Kitagawa Atsushi, Jacob Christina, Hashimoto Ryota, Dhagia Vidhi, Ramesh Amrit, Zheng Connie, Zhang Hui, Jordan Allan, Waddell Ian, Leopold Jane, Hu Cheng-Jun, McMurtry Ivan F, D'Alessandro Angelo, Stenmark Kurt R, Gupte Sachin A
Abstract excerpt
Metabolic reprogramming is considered important in the pathogenesis of the occlusive vasculopathy observed in pulmonary hypertension (PH). However, the mechanisms that link reprogrammed metabolism to aberrant expression of genes, which modulate functional phenotypes of cells in PH, remain enigmatic. Herein, we demonstrate that, in mice, hypoxia-induced PH was prevented by glucose-6-phosphate dehydrogenase...
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