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Article

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.

Science translational medicine - 25 Oct 2017

Michelakis Evangelos D, Gurtu Vikram, Webster Linda, Barnes Gareth, Watson Geoffrey, Howard Luke, Cupitt John, Paterson Ian, Thompson Richard B, Chow Kelvin, O'Regan Declan P, Zhao Lan, Wharton John, Kiely David G, Kinnaird Adam, Boukouris Aristeidis E, White Chris, Nagendran Jayan, Freed Darren H, Wort Stephen J, Gibbs J Simon R, Wilkins Martin R

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a progressive vascular disease with a high mortality rate. It is characterized by an occlusive vascular remodeling due to a pro-proliferative and antiapoptotic environment in the wall of resistance pulmonary arteries (PAs). Proliferating cells exhibit a cancer-like metabolic switch where mitochondrial glucose oxidation is suppressed, whereas glycolysis is up-regulated as...

Topics

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Administration, Oral
Familial Primary Pulmonary Hypertension
Hemodynamics
Perfusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pulmonary Artery

Pyruvate Dehydrogenase Acetyl-Transferring Kinase

Uncoupling Protein 2

Source

Identifiers

PMID: 29070699
DOI: 10.1126/scitranslmed.aao4583

Genes

PAH
SIRT3
UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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