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Article

Hypoxia-inducible factor-1α in pulmonary artery smooth muscle cells lowers vascular tone by decreasing myosin light chain phosphorylation.

Circulation research - 26 Apr 2013

Kim Yu-Mee, Barnes Elizabeth A, Alvira Cristina M, Ying Lihua, Reddy Sushma, Cornfield David N

Abstract excerpt

RATIONALE: Hypoxia-inducible factor-1α (HIF-1α), an oxygen (O2)-sensitive transcription factor, mediates transcriptional responses to low-O2 tension states. Although acute hypoxia causes pulmonary vasoconstriction and chronic hypoxia can cause vascular remodeling and pulmonary hypertension, conflicting data exist on the role of HIF-1α in modulating pulmonary vascular tone. OBJECTIVE: To investigate the role of...

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Source

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Identifiers

PMID: 23513056
DOI: 10.1161/CIRCRESAHA.112.300646
PMCID: PMC4005857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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