Article
PKG-1α leucine zipper domain defect increases pulmonary vascular tone: implications in hypoxic pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology - 1 Oct 2014
Ramchandran Ramaswamy, Raghavan Aarti, Geenen David, Sun Miranda, Bach Laura, Yang Qiwei, Raj J Usha
Abstract excerpt
Pulmonary hypertension (PH) is a chronic disease characterized by a progressive increase in vasomotor tone, narrowing of the vasculature with structural remodeling, and increase in pulmonary vascular resistance. Current treatment strategies include nitric oxide therapy and methods to increase cGMP-mediated vasodilatation. cGMP-dependent protein kinases (PKG) are known mediators of nitric oxide- and cGMP-induced...
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