Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase and myocardin.

American journal of physiology. Lung cellular and molecular physiology - 1 May 2009

Zhou Weilin, Negash Sewite, Liu Jie, Raj J Usha

Abstract excerpt

We have previously reported that in ovine fetal pulmonary venous smooth muscle cells (FPVSMC), decreased expression of cGMP-dependent protein kinase (PKG) by hypoxia could explain hypoxia-induced SMC phenotype modulation. In this study, we investigated the role of myocardin, a possible downstream effector of PKG, in SMC phenotype modulation induced by 1 and 24 h of hypoxia. Hypoxia for 1 h induced the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Hypoxia
Share to Cyclic GMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ets-Domain Protein Elk-1

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Myosin Heavy Chains

Share to Serum Response Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 19251841
DOI: 10.1152/ajplung.90295.2008
PMCID: PMC2681345

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase and myocardin.PMID 19251841Read ↗

Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase.Semantic proximity Read ↗

Contribution of myocardin in the hypoxia-induced phenotypic switching of rat pulmonary arterial smooth muscle cells.Semantic proximity Read ↗

Role of MiR‐542‐3p/Integrin‐Linked Kinase/Myocardin Signaling Axis in Hypoxic Pulmonary HypertensionSemantic proximity Read ↗

An overview of potential molecular mechanisms involved in VSMC phenotypic modulation.Semantic proximity Read ↗

Expressional regulation of smooth muscle cell-specific genes in association with phenotypic modulation.Semantic proximity Read ↗

PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells.Semantic proximity Read ↗

MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells.Semantic proximity Read ↗

Over-expression of PKGIα inhibits hypoxia-induced proliferation, Akt activation, and phenotype modulation of human PASMCs: the role of phenotype modulation of PASMCs in pulmonary vascular remodeling.Semantic proximity Read ↗

Hypoxia-inducible factor-1α in pulmonary artery smooth muscle cells lowers vascular tone by decreasing myosin light chain phosphorylation.Semantic proximity Read ↗

Lung smooth muscle differentiation.Semantic proximity Read ↗

Exosomes derived from hypoxic alveolar epithelial cells promote the phenotypic transformation of pulmonary artery smooth muscle cells via the Rap1 pathway.Semantic proximity Read ↗

A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.