Kinetics of tyrosine phosphorylation and internalization of human EGF receptors overexpressed in NIH 3T3 fibroblasts.

doi:10.1016/0014-4827(90)90022-3

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Article

Kinetics of tyrosine phosphorylation and internalization of human EGF receptors overexpressed in NIH 3T3 fibroblasts.

Experimental cell research - 1 Dec 1990

Sturani E, Zippel R, Morello L, Brambilla R, Comoglio P M, Alberghina L

Abstract excerpt

Binding of epidermal growth factor (EGF) to cells rapidly induces tyrosine phosphorylation of its receptor which is followed by its internalization and dephosphorylation. The kinetics of these processes differs widely in time from minutes to hours according to cell types. In this paper we analyze...

Topics

Calcium
Cell Line
ErbB Receptors
Fibroblasts
Gene Expression
Humans
Inositol Phosphates
Phenotype
Phosphorylation
Signal Transduction
Transfection
Tyrosine

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