Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor.

Nature - 1 Jan 2000

Chen W S, Lazar C S, Poenie M, Tsien R Y, Gill G N, Rosenfeld M G

Abstract excerpt

The epidermal growth factor (EGF) receptor is a transmembrane glycoprotein of relative molecular mass 170,000 with intrinsic ligand-dependent protein tyrosine kinase activity. Binding of EGF to its receptor activates a number of immediate biochemical processes, such as alterations of intracellular free calcium, pH, and increased transcription of several responsive genes, which usually culminate many hours later...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Cell Line
Share to Cricetinae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phosphorylation

Share to Transcription, Genetic

Share to Transfection

Source

Identifiers

PMID: 3498122
DOI: 10.1038/328820a0

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor.PMID 3498122Read ↗

Regulation of EGF receptor expression and function.Semantic proximity Read ↗

Augmented desensitization to epidermal growth factor (EGF) immediate actions: a novel mechanism for altered EGF growth response in mutant A431 cells.Semantic proximity Read ↗

Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.Semantic proximity Read ↗

Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.Semantic proximity Read ↗

Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins.Semantic proximity Read ↗

Stimulation of mitogenic pathways through kinase-impaired mutants of the epidermal growth factor receptor.Semantic proximity Read ↗

Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis.Semantic proximity Read ↗

All Good Things Must End: Termination of Receptor Tyrosine Kinase Signal.Semantic proximity Read ↗

Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol-3 kinase but show differential defects in their ability to induce early response gene transcription.Semantic proximity Read ↗

Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain.Semantic proximity Read ↗

A negative feedback loop attenuates EGF-induced morphological changes.Semantic proximity Read ↗

Structural analysis of the transmembrane domain of the epidermal growth factor receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.