Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor.

doi:10.1038/328820a0

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Article

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor.

Nature - 1 Jan 2000

Chen W S, Lazar C S, Poenie M, Tsien R Y, Gill G N, Rosenfeld M G

Abstract excerpt

The epidermal growth factor (EGF) receptor is a transmembrane glycoprotein of relative molecular mass 170,000 with intrinsic ligand-dependent protein tyrosine kinase activity. Binding of EGF to its receptor activates a number of immediate biochemical processes, such as alterations of intracellula...

Topics

Animals
Calcium
Cell Division
Cell Line
Cricetinae
DNA, Recombinant
Epidermal Growth Factor
ErbB Receptors
L Cells
Mice
Mutation
Oncogenes
Phosphorylation
Protein-Tyrosine Kinases
Transcription, Genetic
Transfection

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