Article
Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis.
Biochemical and biophysical research communications - 11 Feb 2005
Ceridono Mara, Belleudi Francesca, Ceccarelli Simona, Torrisi Maria Rosaria
Abstract excerpt
Keratinocyte growth factor receptor (KGFR) is a receptor tyrosine kinase expressed on epithelial cells which belongs to the family of fibroblast growth factor receptors (FGFRs). Following ligand binding, KGFR is rapidly autophosphorylated on specific tyrosine residues in the intracellular domain, recruits substrate proteins, and is rapidly internalized by clathrin-mediated endocytosis. The role of different...
Topics
- Animals
- Cell Proliferation
- Endocytosis
- Fibroblast Growth Factor 7
- Fibroblast Growth Factors
- Humans
- MAP Kinase Signaling System
- Mice
- Mutation
- Phospholipase C gamma
- Phosphoproteins
- Phosphorylation
- Phosphotyrosine
- Protein Binding