Article
Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells.
The Journal of cell biology - 1 May 1990
Honegger A M, Schmidt A, Ullrich A, Schlessinger J
Abstract excerpt
Ligand binding to the membrane receptor for EGF induces its clustering and internalization. Both receptor and ligand are then degraded by lysosomal enzymes. A kinase defective point mutant (K721A) of EGF receptor undergoes internalization similarly to the wild-type receptor. However, while internalized EGF molecules bound to either the wild-type or mutant receptors are degraded, the K721A mutant receptor...
Topics
- Animals
- Clone Cells
- Cross-Linking Reagents
- Down-Regulation
- Endocytosis
- Epidermal Growth Factor
- ErbB Receptors
- Ethyldimethylaminopropyl Carbodiimide
- Half-Life
- Iodine Radioisotopes
- Kinetics