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Article

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body.

Cell - 18 May 1990

Felder S, Miller K, Moehren G, Ullrich A, Schlessinger J, Hopkins C R

Abstract excerpt

We compared the internalization and intracellular sorting of epidermal growth factor receptor (EGF-R) and point mutant kinase-negative EGF-R separately expressed in NIH 3T3 cells lacking endogenous receptor. Both EGF-Rs internalized rapidly, but kinase-negative receptor was surface down-regulated only with monensin or at 20 degrees C. Furthermore, EGF internalized by mutant receptor alone was, in significant...

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Source

Identifiers

PMID: 2344614
DOI: 10.1016/0092-8674(90)90474-s

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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