Article
A negative feedback loop attenuates EGF-induced morphological changes.
The Journal of cell biology - 1 Aug 1991
Welsh J B, Gill G N, Rosenfeld M G, Wells A
Abstract excerpt
Activation of the EGF receptor tyrosine kinase by ligand indirectly activates a series of other cellular enzymes, including protein kinase C. To test the hypothesis that phosphorylation of the EGF receptor by protein kinase C provides an intracellular negative feedback loop to attenuate EGF recep...
Topics
- Alanine
- Animals
- Cell Line
- Down-Regulation
- Electrophoresis, Polyacrylamide Gel
- Enzyme Activation
- Epidermal Growth Factor
- ErbB Receptors
- Feedback
- Humans
- Microscopy, Electron, Scanning
- Mutation
- Phosphorylation
- Protein Kinase C
- Tetradecanoylphorbol Acetate