Article
Whole genome sequencing of matched primary and metastatic acral melanomas.
Genome research - 1 Feb 2012
Turajlic Samra, Furney Simon J, Lambros Maryou B, Mitsopoulos Costas, Kozarewa Iwanka, Geyer Felipe C, Mackay Alan, Hakas Jarle, Zvelebil Marketa, Lord Christopher J, Ashworth Alan, Thomas Meirion, Stamp Gordon, Larkin James, Reis-Filho Jorge S, Marais Richard
Abstract excerpt
Next generation sequencing has enabled systematic discovery of mutational spectra in cancer samples. Here, we used whole genome sequencing to characterize somatic mutations and structural variation in a primary acral melanoma and its lymph node metastasis. Our data show that the somatic mutational rates in this acral melanoma sample pair were more comparable to the rates reported in cancer genomes not associated...
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