Article
Unexpected UVR and non-UVR mutation burden in some acral and cutaneous melanomas.
Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2017
Rawson Robert V, Johansson Peter A, Hayward Nicholas K, Waddell Nicola, Patch Ann-Marie, Lo Serigne, Pearson John V, Thompson John F, Mann Graham J, Scolyer Richard A, Wilmott James S
Abstract excerpt
Ultraviolet radiation (UVR) mutagenesis causes nearly all cutaneous melanomas, however, since UVR signatures are largely absent in acral melanoma, as well as melanoma in sun-protected sites, the cause of these melanomas is unknown. Whole-genome sequencing data generated as part of the Australian Melanoma Genome Project was supplemented with a detailed histopathological assessment with the melanomas then...
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