Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: Voxel-based morphometry analysis.

doi:10.1016/j.pscychresns.2015.07.024

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Article

Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: Voxel-based morphometry analysis.

Psychiatry research - 30 Sept 2015

Watanabe Keita, Kakeda Shingo, Yoshimura Reiji, Abe Osamu, Ide Satoru, Hayashi Kenji, Katsuki Asuka, Umene-Nakano Wakako, Watanabe Rieko, Nakamura Jun, Korogi Yukunori

Abstract excerpt

Catechol-O-methyltransferase (COMT) is a methylation enzyme engaged in the degradation of dopamine and noradrenaline by catalyzing the transfer of a methyl group from S-adenosylmethionine. An association was found between the Valine (Val) 108/158Methionine (Met) COMT polymorphism (rs4680) and major depressive disorder (MDD). The authors prospectively investigated the relationship between the Val108/158Met COMT...

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PMID: 26253436
DOI: 10.1016/j.pscychresns.2015.07.024

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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