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Article

Effect of Functional BDNF and COMT Polymorphisms on Symptoms and Regional Brain Volume in Frontotemporal Dementia and Corticobasal Syndrome.

The Journal of neuropsychiatry and clinical neurosciences - 1 Jan 2020

Huey Edward D, Fremont Rachel, Manoochehri Masood, Gazes Yunglin, Lee Seonjoo, Cosentino Stephanie, Tierney Michael, Wassermann Eric M, Momeni Parastoo, Grafman Jordan

Abstract excerpt

OBJECTIVE: The authors examined the effects of two common functional polymorphisms-brain-derived neurotrophic factor (BDNF) Val66Met and catechol-O-methyltransferase (COMT) Val158Met-on cognitive, neuropsychiatric, and motor symptoms and MRI findings in persons with frontotemporal lobar degeneration (FTLD) syndromes. METHODS: The BDNF Val66Met and COMT Val158Met polymorphisms were genotyped in 174 participants...

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Identifiers

PMID: 32397876
DOI: 10.1176/appi.neuropsych.19100211
PMCID: PMC7606216

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