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Article

The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease.

Neurobiology of aging - 1 Jun 2010

Rowe J B, Hughes L, Williams-Gray C H, Bishop S, Fallon S, Barker R A, Owen A M

Abstract excerpt

We investigated whether the val(158)met functional polymorphism of catechol-o-methyltransferase influenced age-related changes in grey matter density and volume, both in healthy individuals (n=80, ages 18-79) and those with Parkinson's disease (n=50). Global grey matter volumes and voxelwise estimates of grey matter volume and density were determined from structural magnetic resonance images at 3T. Male and...

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Identifiers

PMID: 18755526
DOI: 10.1016/j.neurobiolaging.2008.07.009
PMCID: PMC3898476

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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