Article
LAHEDES: the LAGLIDADG homing endonuclease database and engineering server.
Nucleic acids research - 1 Jul 2012
Taylor Gregory K, Petrucci Lucas H, Lambert Abigail R, Baxter Sarah K, Jarjour Jordan, Stoddard Barry L
Abstract excerpt
LAGLIDADG homing endonucleases (LHEs) are DNA cleaving enzymes, also termed 'meganucleases' that are employed as gene-targeting reagents. This use of LHEs requires that their DNA specificity be altered to match sequences in genomic targets. The choice of the most appropriate LHE to target a particular gene is facilitated by the growing number of such enzymes with well-characterized activities and structures....
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