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Article

In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination.

Nucleic acids research - 23 Nov 2005

Chames Patrick, Epinat Jean-Charles, Guillier Sophie, Patin Amélie, Lacroix Emmanuel, Pâques Frédéric

Abstract excerpt

Homing endonucleases, endonucleases capable of recognizing long DNA sequences, have been shown to be a tool of choice for precise and efficient genome engineering. Consequently, the possibility to engineer novel endonucleases with tailored specificities is under strong investigation. In this report, we present a simple and efficient method to select meganucleases from libraries of variants, based on their...

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PMID: 16306233
DOI: 10.1093/nar/gni175
PMCID: PMC1289081

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