Article
Evolutionarily conserved and functionally important residues in the I-CeuI homing endonuclease.
Nucleic acids research - 1 Jul 1997
Turmel M, Otis C, Côté V, Lemieux C
Abstract excerpt
Two approaches were used to discern critical amino acid residues for the function of the I- Ceu I homing endonuclease: sequence comparison of subfamilies of homologous proteins and genetic selection. The first approach revealed residues potentially involved in catalysis and DNA recognition. Becau...
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