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Article

Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2014

McMurrough Thomas A, Dickson Russell J, Thibert Stephanie M F, Gloor Gregory B, Edgell David R

Abstract excerpt

The active sites of enzymes consist of residues necessary for catalysis and structurally important noncatalytic residues that together maintain the architecture and function of the active site. Examples of evolutionary interactions between catalytic and noncatalytic residues have been difficult to define and experimentally validate due to a general intolerance of these residues to substitution. Here, using...

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Identifiers

PMID: 24912189
DOI: 10.1073/pnas.1322352111
PMCID: PMC4060692

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