Article
Interleukin-10 (IL-10) polymorphisms are associated with IL-10 production and clinical malaria in young children.
Infection and immunity - 1 Jul 2012
Zhang Guicheng, Manaca Maria Nelia, McNamara-Smith Michelle, Mayor Alfredo, Nhabomba Augusto, Berthoud Tamara Katherine, Khoo Siew-Kim, Wiertsema Selma, Aguilar Ruth, Barbosa Arnoldo, Quintó Llorenç, Candelaria Pierre, Schultz En Nee, Hayden Catherine M, Goldblatt Jack, Guinovart Caterina, Alonso Pedro L, Lesouëf Peter N, Dobaño Carlota
Abstract excerpt
The role of interleukin-10 (IL-10) in malaria remains poorly characterized. The aims of this study were to investigate (i) whether genetic variants of the IL-10 gene influence IL-10 production and (ii) whether IL-10 production as well as the genotypes and haplotypes of the IL-10 gene in young children and their mothers are associated with the incidence of clinical malaria in young children. We genotyped three...
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