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Article

IL10A genotypic association with decreased IL-10 circulating levels in malaria infected individuals from endemic area of the Brazilian Amazon.

Malaria journal - 28 Jan 2015

Pereira Virginia A, Sánchez-Arcila Juan C, Teva Antonio, Perce-da-Silva Daiana S, Vasconcelos Mariana P A, Lima Cleoni A M, Aprígio Cesarino J L, Rodrigues-da-Silva Rodrigo N, Santos Davi O, Banic Dalma M, Bonecini-Almeida Maria G, Lima-Júnior Josué C, Oliveira-Ferreira Joseli

Abstract excerpt

BACKGROUND: Cytokines play an important role in human immune responses to malaria and variation in their production may influence the course of infection and determine the outcome of the disease. The differential production of cytokines has been linked to single nucleotide polymorphisms in gene promoter regions, signal sequences, and gene introns. Although some polymorphisms play significant roles in...

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PMID: 25627396
DOI: 10.1186/s12936-015-0548-z
PMCID: PMC4334410

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