Article
Increased interleukin-10 and interferon-γ levels in Plasmodium vivax malaria suggest a reciprocal regulation which is not altered by IL-10 gene promoter polymorphism.
Malaria journal - 14 Sept 2011
Medina Tiago S, Costa Sheyla P T, Oliveira Maria D, Ventura Ana M, Souza José M, Gomes Tassia F, Vallinoto Antonio C R, Póvoa Marinete M, Silva João S, Cunha Maristela G
Abstract excerpt
BACKGROUND: In human malaria, the naturally-acquired immune response can result in either the elimination of the parasite or a persistent response mediated by cytokines that leads to immunopathology. The cytokines are responsible for all the symptoms, pathological alterations and the outcome of the infection depends on the reciprocal regulation of the pro and anti-inflammatory cytokines. IL-10 and IFN-gamma are...
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