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Article

The influence of genetic variation on innate immune activation in an environment with high infectious pressure.

Genes and immunity - 1 Feb 2012

Boef A G C, May L, van Bodegom D, Kuningas M, Eriksson U K, Westendorp R G J

Abstract excerpt

Interleukin-10 (IL-10) production is under tight genetic control in populations living in affluent environments. However, little is known about the role of IL10 genetics on cytokine production in populations living in environments with high infectious pressure. We have previously reported that, in a rural Ghanaian population, the most common IL10 haplotype associates with a pro-inflammatory response. Here, we aim...

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PMID: 21833021
DOI: 10.1038/gene.2011.57

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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