Linking yeast Gcn5p catalytic function and gene regulation using a quantitative, graded dominant mutant approach.

Abstract excerpt

Establishing causative links between protein functional domains and global gene regulation is critical for advancements in genetics, biotechnology, disease treatment, and systems biology. This task is challenging for multifunctional proteins when relying on traditional approaches such as gene deletions since they remove all domains simultaneously. Here, we describe a novel approach to extract quantitative,...

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