Article
Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.
Genes & development - 1 Mar 1998
Wang L, Liu L, Berger S L
Abstract excerpt
Several previously known transcription cofactors have been demonstrated in vitro recently to be histone acetyltransferases and deacetyltransferases, suggesting that remodeling of chromatin through histone acetylation plays a fundamental role in gene regulation. Clear evidence has not yet been obt...
Topics
- Acetylation
- Alanine
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- DNA-Binding Proteins
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genetic Complementation Test
- Histone Acetyltransferases
- Histones
- Molecular Sequence Data
- Mutation
- Protein Kinases
- Saccharomyces cerevisiae Proteins
- Transcription Factors
- Transcription, Genetic
- Transcriptional Activation