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Article

Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo.

Genes & development - 1 Mar 1998

Kuo M H, Zhou J, Jambeck P, Churchill M E, Allis C D

Abstract excerpt

Gcn5p is a transcriptional coactivator required for correct expression of various genes in yeast. Several transcriptional regulators, including Gcn5p, possess intrinsic histone acetyltransferase (HAT) activity in vitro. However, whether the HAT activity of any of these proteins is required for gene activation remains unclear. Here, we demonstrate that the HAT activity of Gcn5p is critical for transcriptional...

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Identifiers

PMID: 9499399
DOI: 10.1101/gad.12.5.627
PMCID: PMC316582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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