Article
High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch.
Metabolic engineering - 1 Jul 2012
Michener Joshua K, Smolke Christina D
Abstract excerpt
Metabolic engineering can produce a wide range of bulk and fine chemicals using renewable resources. These approaches frequently require high levels of activity from multiple heterologous enzymes. Directed evolution techniques have been used to improve the activity of a wide range of enzymes but can be difficult to apply when the enzyme is used in whole cells. To address this limitation, we developed...
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