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RNAi-assisted genome evolution in Saccharomyces cerevisiae for complex phenotype engineering.

ACS synthetic biology - 20 Mar 2015

Si Tong, Luo Yunzi, Bao Zehua, Zhao Huimin

Abstract excerpt

A fundamental challenge in basic and applied biology is to reprogram cells with improved or novel traits on a genomic scale. However, the current ability to reprogram a cell on the genome scale is limited to bacterial cells. Here, we report RNA interference (RNAi)-assisted genome evolution (RAGE) as a generally applicable method for genome-scale engineering in the yeast Saccharomyces cerevisiae. Through iterative...

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PMID: 24758359
DOI: 10.1021/sb500074a

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