Article

A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors

2020-05-31

Abstract excerpt

Biosensors are key components in engineered biological systems, providing a means of measuring and acting upon the large biochemical space in living cells. However, generating small molecule sensing elements and integrating them into in vivo biosensors have been challenging. Using aptamer-coupled ribozyme libraries and a novel ribozyme regeneration method, we developed de novo rapid in vitro evolution of RNA bi...

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Literature Corpus work: b8a9e7c0-5b91-52fe-a211-c20bddf53fb8
DOI: 10.1101/2020.05.29.117960

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