Tools for genome-wide strain design and construction.

doi:10.1016/j.copbio.2012.01.012

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Article

Tools for genome-wide strain design and construction.

Current opinion in biotechnology - 1 Oct 2012

Boyle Nanette R, Gill Ryan T

Abstract excerpt

Advances in DNA sequencing and synthesis technologies concurrent with the development of new recombinant DNA approaches have enabled the extension of directed evolution algorithms to the genome-scale. It is now possible to simultaneously map the effect of mutation(s) in each and every gene in the genome onto almost any screenable or selectable phenotype in less than a week. Such maps can be used to direct the...

Topics

Bacteria
Directed Molecular Evolution
Genetic Engineering
Genome, Bacterial
Metabolic Engineering
Mutation
Phenotype
Sequence Analysis

Source

Open in PubMed

Identifiers

PMID: 22357141
DOI: 10.1016/j.copbio.2012.01.012

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