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Article

Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Aug 2012

Wierenga Christina E, Dev Sheena I, Shin David D, Clark Lindsay R, Bangen Katherine J, Jak Amy J, Rissman Robert A, Liu Thomas T, Salmon David P, Bondi Mark W

Abstract excerpt

Using whole-brain pulsed arterial spin labeling magnetic resonance imaging, resting cerebral blood flow (CBF) was measured in 20 mild cognitive impairment (MCI; 11 ɛ3 and 9 ɛ4) and 40 demographically matched cognitively normal (CN; 27 ɛ3 and 13 ɛ4) participants. An interaction of apolipoprotein (APOE) genotype (ɛ3 and ɛ4) and cognitive status (CN and MCI) on quantified gray-matter CBF corrected for partial volume...

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Source

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Identifiers

PMID: 22549621
DOI: 10.1038/jcbfm.2012.58
PMCID: PMC3421098

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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