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Article

Arterial spin labeling imaging reveals widespread and Aβ-independent reductions in cerebral blood flow in elderly apolipoprotein epsilon-4 carriers.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Mar 2016

Michels Lars, Warnock Geoffrey, Buck Alfred, Macauda Gianluca, Leh Sandra E, Kaelin Andrea M, Riese Florian, Meyer Rafael, O'Gorman Ruth, Hock Christoph, Kollias Spyros, Gietl Anton F

Abstract excerpt

Changes in cerebral blood flow are an essential feature of Alzheimer's disease and have been linked to apolipoprotein E-genotype and cerebral amyloid-deposition. These factors could be interdependent or influence cerebral blood flow via different mechanisms. We examined apolipoprotein E-genotype, amyloid beta-deposition, and cerebral blood flow in amnestic mild cognitive impairment using pseudo-continuous...

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Identifiers

PMID: 26661143
DOI: 10.1177/0271678X15605847
PMCID: PMC4794091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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