Article
Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner.
Neurobiology of aging - 1 Apr 2015
Gietl Anton F, Warnock Geoffrey, Riese Florian, Kälin Andrea M, Saake Antje, Gruber Esmeralda, Leh Sandra E, Unschuld Paul G, Kuhn Felix P, Burger Cyrill, Mu Linjing, Seifert Burkhardt, Nitsch Roger M, Schibli Roger, Ametamey Simon M, Buck Alfred, Hock Christoph
Abstract excerpt
Early uptake of [(11)C]-Pittsburgh Compound B (ePiB, 0-6 minutes) estimates cerebral blood flow. We studied ePiB in 13 PiB-negative and 10 PiB-positive subjects with mild cognitive impairment (MCI, n = 23) and 11 PiB-positive and 74 PiB-negative cognitively healthy elderly control subjects (HCS, n = 85) in 6 bilateral volumes of interest: posterior cingulate cortex (PCC), hippocampus (hipp), temporoparietal...
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