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Article

Regional hyperperfusion in cognitively normal APOE ε4 allele carriers in mid-life: analysis of ASL pilot data from the PREVENT-Dementia cohort.

Journal of neurology, neurosurgery, and psychiatry - 1 Aug 2020

McKiernan Elizabeth Frances, Mak Elijah, Dounavi Maria-Eleni, Wells Katie, Ritchie Craig, Williams Guy, Su Li, O'Brien John

Abstract excerpt

BACKGROUND: Regional cerebral hypoperfusion is characteristic of Alzheimer's disease (AD). Previous studies report conflicting findings in cognitively normal individuals at high risk of AD. Understanding early preclinical perfusion alterations may improve understanding of AD pathogenesis and lead to new biomarkers and treatment targets. METHODS: 3T arterial spin labelling MRI scans from 162 participants in the...

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Identifiers

PMID: 32586852
DOI: 10.1136/jnnp-2020-322924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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