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Article

Differential effects of the APOE genotype on brain function across the lifespan.

NeuroImage - 1 Jan 2011

Filippini N, Ebmeier K P, MacIntosh B J, Trachtenberg A J, Frisoni G B, Wilcock G K, Beckmann C F, Smith S M, Matthews P M, Mackay C E

Abstract excerpt

Increasing age and carrying an APOE ε4 allele are well established risk factors for Alzheimer's disease (AD). The earlier age of onset of AD observed in ε4-carriers may reflect an accelerated aging process. We recently reported that APOE genotype modulates brain function decades before the appearance of any cognitive or clinical symptoms. Here we test the hypothesis that APOE influences brain aging by comparing...

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Source

Identifiers

PMID: 20705142
DOI: 10.1016/j.neuroimage.2010.08.009

Genes

APOE

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