Article
Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2012
Williams Jan M, Johnson Ashley C, Stelloh Cary, Dreisbach Albert W, Franceschini Nora, Regner Kevin R, Townsend Raymond R, Roman Richard J, Garrett Michael R
Abstract excerpt
A previous genetic analysis comparing the Dahl salt-sensitive (S) rat with the spontaneously hypertensive rat identified a major locus on chromosome 2 that influences proteinuria in the S rat. In the present study, blood pressure, proteinuria, and renal hemodynamics were evaluated in congenic strains with small segments of the protective spontaneously hypertensive rat genome on the S background. Proteinuria and...
Topics
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- Animals
- Animals, Congenic
- Blood Pressure
- Blotting, Western
- Chromosome Mapping
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Guanine Nucleotide Exchange Factors