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SORCS1 contributes to the development of renal disease in rats and humans.

Physiological genomics - 15 Aug 2013

Lazar Jozef, O'Meara Caitlin C, Sarkis Allison B, Prisco Sasha Z, Xu Haiyan, Fox Caroline S, Chen Ming-Huei, Broeckel Ulrich, Arnett Donna K, Moreno Carol, Provoost Abraham P, Jacob Howard J

Abstract excerpt

Many lines of evidence demonstrate that genetic variability contributes to chronic kidney disease susceptibility in humans as well as rodent models. Little progress has been made in discovering causal kidney disease genes in humans mainly due to genetic complexity. Here, we use a minimal congenic mapping strategy in the FHH (fawn hooded hypertensive) rat to identify Sorcs1 as a novel renal disease candidate gene....

Topics

Animals
Biological Transport
Female
Genotype
Humans
Hypertension
Kidney Diseases
Kidney Tubules, Proximal
Male
Proteinuria
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Cell Surface

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Open in PubMed Open full text

Identifiers

PMID: 23780848
DOI: 10.1152/physiolgenomics.00089.2013
PMCID: PMC3742914

Genes

SORCS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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