Proteinuria and glomerulosclerosis in the Sabra genetic rat model of salt susceptibility.

doi:10.1152/physiolgenomics.00014.2002

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Article

Proteinuria and glomerulosclerosis in the Sabra genetic rat model of salt susceptibility.

Physiological genomics - 1 Jan 2002

Yagil Chana, Sapojnikov Marina, Katni Gurion, Ilan Zvi, Zangen Sarah Weksler, Rosenmann Eliezer, Yagil Yoram

Abstract excerpt

In search of an experimental model that would simulate the association between proteinuria and salt sensitivity in humans, we studied protein excretion in the Sabra rat model of salt susceptibility. Monthly measurements of urinary protein excretion in animals fed standard rat chow revealed that normotensive salt-sensitive SBH/y developed proteinuria that averaged 65 +/- 7 mg/day (n = 10) at 9 mo, whereas...

Topics

Age Factors
Animal Feed
Animals
Blood Pressure
Chromosomes
Diet
Disease Models, Animal
Disease Susceptibility
Female
Genetic Markers
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glomerulosclerosis, Focal Segmental

Hypertension

Kidney

Male

Proteinuria

Quantitative Trait, Heritable

Rats

Source

Open in PubMed

Identifiers

PMID: 12045297
DOI: 10.1152/physiolgenomics.00014.2002

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