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Article

Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial-Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat.

PloS one - 1 Jan 2015

Jia Zhen, Johnson Ashley C, Wang Xuexiang, Guo Zibiao, Dreisbach Albert W, Lewin Jack R, Kyle Patrick B, Garrett Michael R

Abstract excerpt

Previously, genetic analyses identified that variants in Arhgef11 may influence kidney injury in the Dahl salt-sensitive (S) rat, a model of hypertensive chronic kidney disease. To understand the potential mechanism by which altered expression and/or protein differences in Arhgef11 could play a role in kidney injury, stably transduced Arhgef11 knockdown cell lines as well as primary cultures of proximal tubule...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Rats, Inbred Dahl

Share to Rats, Inbred SHR

Share to Renal Insufficiency, Chronic

Share to rho-Associated Kinases

Share to rho GTP-Binding Proteins

Share to Rho Guanine Nucleotide Exchange Factors

Source

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Identifiers

PMID: 26172442
DOI: 10.1371/journal.pone.0132553
PMCID: PMC4501567

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NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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