Article
Investigating the effect of genetic background on proteinuria and renal injury using two hypertensive strains.
American journal of physiology. Renal physiology - 1 Apr 2009
Packard Matthew, Saad Yasser, Gunning William T, Gupta Shalini, Shapiro Joseph, Garrett Michael R
Abstract excerpt
An earlier linkage analysis conducted on a population derived from the Dahl salt-sensitive hypertensive (S) and the spontaneously hypertensive rat (SHR) identified 10 genomic regions linked to several renal and/or cardiovascular traits. In particular, loci on rat chromosomes (RNO) 8 and 13 were linked to proteinuria, albuminuria, and renal damage. At both loci, the S allele was associated with increased...
Topics
- Animals
- Animals, Congenic
- Disease Models, Animal
- Fibrosis
- Genetic Linkage
- Genetic Predisposition to Disease
- Hypertension
- Kidney
- Kidney Diseases
- Male
- Phenotype
- Proteinuria
- Quantitative Trait Loci