Article
Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus.
Kidney international - 1 Nov 2007
Salzler H R, Griffiths R, Ruiz P, Chi L, Frey C, Marchuk D A, Rockman H A, Le T H
Abstract excerpt
Chronic kidney disease (CKD) is a key cause of hypertension and a potent independent risk for cardiovascular disease. Epidemiological studies suggest a strong genetic component determining susceptibility for renal disease and, by inference, the associated cardiovascular risk. With a subtotal nephrectomy model of kidney disease, we found the 129S6 mouse strain to be very susceptible to the development of...
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