Article
Somatic deletions of the polyA tract in the 3' untranslated region of epidermal growth factor receptor are common in microsatellite instability-high endometrial and colorectal carcinomas.
Archives of pathology & laboratory medicine - 1 May 2012
Deqin Ma, Chen Zhao, Nero Christopher, Patel Keyur P, Daoud Emad M, Cheng Hanyin, Djordjevic Bojana, Broaddus Russell R, Medeiros L Jeffrey, Rashid Asif, Luthra Rajyalakshmi
Abstract excerpt
CONTEXT: Epidermal growth factor receptor (EGFR) is overexpressed in up to 80% of colorectal and endometrial carcinomas. Deletions of the polyA tract in the 3' untranslated region (3' UTR) have been reported in microsatellite instability-high (MSI-H) colonic carcinomas, but their impacts on EGFR...
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