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Article

Oncogenic mutations in gastric cancer with microsatellite instability.

European journal of cancer (Oxford, England : 1990) - 1 Feb 2011

Corso Giovanni, Velho Sérgia, Paredes Joana, Pedrazzani Corrado, Martins Diana, Milanezi Fernanda, Pascale Valeria, Vindigni Carla, Pinheiro Hugo, Leite Marina, Marrelli Daniele, Sousa Sónia, Carneiro Fátima, Oliveira Carla, Roviello Franco, Seruca Raquel

Abstract excerpt

AIM: Mitogen-activated protein kinase (MAPK) cascade and phosphatidylinositol 3-kinase (PI3K) survival pathways are frequently activated in the progression of gastrointestinal malignancies. In this study, we aimed to determine the frequency of gene mutations in members of these pathways--Epithelial Growth Factor Receptor (EGFR), KRAS, BRAF, PIK3CA and MLK3 in a series of 63 gastric carcinomas with high levels of...

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Source

Identifiers

PMID: 20937558
DOI: 10.1016/j.ejca.2010.09.008

Genes

EGFR
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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