Article
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.
Oncogene - 8 Apr 2004
Giannini Giuseppe, Rinaldi Christian, Ristori Elisabetta, Ambrosini Maria Irene, Cerignoli Fabio, Viel Alessandra, Bidoli Ettore, Berni Silvia, D'Amati Giulia, Scambia Giovanni, Frati Luigi, Screpanti Isabella, Gulino Alberto
Abstract excerpt
Frequent mutations of coding nucleotide repeats are thought to contribute significantly to carcinogenesis associated with microsatellite instability (MSI). We have shown that shortening of the poly(T)11 within the polypyrimidine stretch/accessory splicing signal of human MRE11 leads to the reduced expression and functional impairment of the MRE11/NBS1/RAD50 complex. This mutation was selectively found in mismatch...
Topics
- Aged
- Alleles
- Base Pair Mismatch
- Cell Cycle Proteins
- Cell Line
- Colorectal Neoplasms
- DNA Repair
- DNA Sequence, Unstable
- DNA-Binding Proteins
- Endodeoxyribonucleases