Article
An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.
Cancer research - 1 Oct 2009
Yuan Ziqiang, Shin Joongho, Wilson Andrew, Goel Sanjay, Ling Yi-He, Ahmed Naseem, Dopeso Higinio, Jhawer Minaxi, Nasser Shannon, Montagna Cristina, Fordyce Kenneth, Augenlicht Leonard H, Aaltonen Lauri A, Arango Diego, Weber Thomas K, Mariadason John M
Abstract excerpt
Colorectal cancers (CRC) with microsatellite instability (MSI) have clinical, pathologic, genetic, and epigenetic features distinct from microsatellite-stable CRC. Examination of epidermal growth factor receptor (EGFR) mRNA and protein expression levels in a panel of colon cancer cell lines identified strong expression of EGFR in multiple cell lines with MSI. Although no relationship between EGFR overexpression...
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