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Article

Down-regulation of epidermal growth factor receptor by selective expansion of a 5'-end regulatory dinucleotide repeat in colon cancer with microsatellite instability.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2009

Baranovskaya Svetlana, Martin Yolanda, Alonso Sergio, Pisarchuk Ksenia L, Falchetti Mario, Dai Yuichi, Khaldoyanidi Sophia, Krajewski Stan, Novikova Inna, Sidorenko Yuri S, Perucho Manuel, Malkhosyan Sergei R

Abstract excerpt

PURPOSE: The epidermal growth factor receptor (EGFR) is overexpressed in several tumor types, and its expression is influenced by the length of a 5'-end microsatellite repeat (CA)n: the longer the repeat, the lower the expression. Dinucleotide repeats accumulate insertion/deletion types of mutations in tumors with microsatellite instability. We designed this study to estimate the occurrence of these mutations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19584170
DOI: 10.1158/1078-0432.CCR-08-1282
PMCID: PMC2885604

Genes

EGFR
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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