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Article

APC mutations dysregulate alternative polyadenylation in cancer.

Genome biology - 7 Oct 2024

Gabel Austin M, Belleville Andrea E, Thomas James D, Pineda Jose Mario Bello, Bradley Robert K

Abstract excerpt

BACKGROUND: Alternative polyadenylation (APA) affects most human genes and is recurrently dysregulated in all studied cancers. However, the mechanistic origins of this dysregulation are incompletely understood. RESULTS: We describe an unbiased analysis of molecular regulators of poly(A) site selection across The Cancer Genome Atlas and identify that colorectal adenocarcinoma is an outlier relative to all other...

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Identifiers

PMID: 39375704
DOI: 10.1186/s13059-024-03406-4
PMCID: PMC11457450

Genes

APC

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